Impact of the CD40-CD40L Dyad in Alzheimers Disease
نویسندگان
چکیده
منابع مشابه
CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system.
CD40 and its cognate ligand (CD40L) are a pair of regulators of pro-inflammatory and immune responses. In the central nervous system (CNS), CD40 is expressed on a variety of cells, including vascular endothelial cells, smooth muscle cells, astrocytes and microglia (the brain macrophages, being the most sensitive cell type to respond to CD40 ligand). Interaction between CD40 on microglia and CD4...
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The CD40-CD40L dyad is an immune checkpoint regulator that promotes both innate and adaptive immune responses and has therefore an essential role in the development of inflammatory diseases, including multiple sclerosis (MS). In MS, CD40 and CD40L are expressed on immune cells present in blood and lymphoid organs, affected resident central nervous system (CNS) cells, and inflammatory cells that...
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ژورنال
عنوان ژورنال: CNS & Neurological Disorders - Drug Targets
سال: 2010
ISSN: 1871-5273
DOI: 10.2174/187152710791012099